UP Manila School of Health Sciences in Aurora (UPSHS-Baler) is an extension campus inaugurated last July 21, 2008 initiated by Sen. Edgardo J. Angara together with then UP President Emerlinda Roman. The UPSHS-Baler campus is said to be the first UP specialized school on health in Luzon which will serve the health needs of people not only in the host province but also in the provinces of Isabela, Nueva Vizcaya, Quirino and Nueva Ecija. It is intended to produce graduates of medicine-related courses who would fill the void caused by the lack of health professionals in the countryside. The students enrolled are currently under a ladderized education curriculum designed to meet the needs of the rural communities. From the basic Community Health, a student can move on to BS Nursing and later on to Doctor of Medicine.
The campus was temporarily operated in the Zabali campus of the Aurora State College of Technology (ASCOT), while the UPSHS building was being constructed. A memorandum of agreement was signed between the UP administration and ASCOT represented by its president, Dr. Eusebio Angara. The campus will rise in a five-hectare lot in Barangay Reserva Baler, Aurora, 230 kilometers north of Manila. The project will be jointly undertaken by the Department of Health and the provincial government.